Brusatol: A potential anti-tumor quassinoid from Brucea javanica
نویسندگان
چکیده
منابع مشابه
Intravenous microemulsion of docetaxel containing an anti-tumor synergistic ingredient (Brucea javanica oil): formulation and pharmacokinetics
The purpose of this study was to develop a docetaxel microemulsion containing an anti-tumor synergistic ingredient (Brucea javanica oil) and to investigate the characteristics of the microemulsion. Brucea javanica oil contains oleic acid and linoleic acids that have been shown by animal and human studies to inhibit tumor formation. The microemulsion containing Brucea javanica oil, medium-chain ...
متن کاملFormulation, preparation and evaluation of an intravenous emulsion containing Brucea javanica oil and Coix Seed oil for anti-tumor application.
The purpose of this study was to prepare and evaluate the intravenous emulsion (BCOE) containing Brucea javanica oil (BJO) and Coix seed oil (CSO), which is used in anti-tumor treatment. The formulation and preparation of BCOE were systematically investigated. High-pressure homogenization, particle size distribution, zeta-potential and HPLC were carried out. The pharmacokinetics of the main com...
متن کاملPhytochemical and antimalarial screening of Brucea javanica plant extracts
The leaf, root, and stem extracts of Brucea javanica were screened for phytochemical properties and antimalarial activity, after extractions with various organic solvents. Qualitative analysis of the phytochemical constituents showed the presence of the following secondary metabolites: terpenoids, saponins, flavonoids, steroids, phenols, glycosides, alkaloids, and anthraquinones. The extracts s...
متن کاملEvaluation of Antidiabetic and Antioxidant Properties of Brucea javanica Seed
The ethanol extract of B. javanica seed was fractionated with solvents of different polarities and tested for antioxidant activities by several assays including DPPH radical scavenging activity, ferric reducing antioxidant power (FRAP), ferrous ion chelating activity (FCA), and nitric oxide radical scavenging activity (NORSA) along with their polyphenolic contents. Antidiabetic activity was eva...
متن کاملIsolation of antibabesial compounds from Brucea javanica, Curcuma xanthorrhiza, and Excoecaria cochinchinensis.
One new curcuminoid, 3'-demethoxycyclocurcumin (1), was isolated from Curcuma xanthorrhiza as an antibabesial compound, together with p-hydroxybenzaldehyde (2) and cleomiscosin A (3) from Brucea javanica and (+)-epiloliolide (4) from Excoecaria cochinchinensis. The antibabesial activities were examined in vitro, and compounds 1-4, and diminazene aceturate were studied with IC(50) values of 16.6...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chinese Herbal Medicines
سال: 2020
ISSN: 1674-6384
DOI: 10.1016/j.chmed.2020.05.007